- Spraggs
- Sprankle Mills
- Spring Church
- Spring City
- Spring Creek
- Spring Glen
- Spring Grove
- Spring House
- Spring Mills
- Spring Mount
- Spring Run
- Springboro
- Springdale
- Springfield
- Springs
- Springtown
- Springville
- Sproul
- Spruce Creek
- Stahlstown
- Star Junction
- Starford
- Starlight
- Starrucca
- State College
- State Line
- Sterling
- Stevens
- Stevensville
- Stewartstown
- Stillwater
- Stockdale
- Stockertown
- Stoneboro
- Stoystown
- Strabane
- Strasburg
- Strattanville
- Strausstown
- Strongstown
- Stroudsburg
- Stump Creek
- Sturgeon
- Sugar Grove
- Sugar Run
- Sugarloaf
- Summerdale
- Summerhill
- Summerville
- Summit Hill
- Summit Station
- Sumneytown
- Sunbury
- Suplee
- Susquehanna
- Sutersville
- Swarthmore
- Sweet Valley
- Swengel
- Swiftwater
- Sybertsville
- Sycamore
- Sykesville
- Sylvania
- Tafton
- Talmage
- Tamaqua
- Tamiment
- Tannersville
- Tarentum
- Tarrs
- Tatamy
- Taylor
- Taylorstown
- Telford
- Temple
- Templeton
- Terre Hill
- Thomasville
- Thompson
- Thompsontown
- Thorndale
- Thornton
- Three Springs
- Tidioute
- Timblin
- Tioga
- Tiona
- Tionesta
- Tipton
- Tire Hill
- Titusville
- Tobyhanna
- Todd
- Topton
- Torrance
- Toughkenamon
- Towanda
- Tower City
- Townville
- Trafford
- Transfer
- Treichlers
- Tremont
- Tresckow
- Trevorton
- Trexlertown
- Trout Run
- Troutville
- Troxelville
- Troy
- Trumbauersville
- Tunkhannock
- Turbotville
- Turkey City
- Turtle Creek
- Turtlepoint
- Tuscarora
- Twin Rocks
- Tyler Hill
- Tylersburg
- Tylersport
- Tyrone
- Uledi
- Ulster
- Ulysses
- Union City
- Union Dale
- Uniontown
- Unionville
- United
- Unity House
- Unityville
- University Park
- Upper Black Eddy
- Upper Darby
- Upperstrasburg
- Ursina
- Utica
- Uwchland
- Valencia
- Valier
- Valley Forge
- Valley View
- Van Voorhis
- Vanderbilt
- Vandergrift
- Venango
- Venetia
- Venus